Home > Help for Families > Info for Families > Trisomy 13 & Trisomy 18 > Related Disorders > Holoprosencephaly (HPE)

Holoprosencephaly (HPE)


Holoprosencephaly is when the front part of the brain fails to develop into clearly separate right and left halves, and although a baby with holoprosencephaly may have normal chromosomes, it is common in trisomy 13. This may severely affect the function of the brain, although among children with this condition there is considerable variability in the degree of malformation and its effects. Babies diagnosed with this condition usually have a small head, excessive fluid in the brain, cleft lip, varying degrees of learning difficulties, epilepsy, hormonal problems, or problems with the heart, bones, bowel or bladder.

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